TFOS DEWS II ReportThe new DEWSII report issued in July 2017 has this to say about preservatives (Section 22.214.171.124.5. Preservatives): "Chronic exposure of the ocular surface to preservatives is now well recognized to induce toxicity and adverse changes to the ocular surface...preservative-free drops may be a better choice for patients who have pre-existing ocular surface conditions and/or need frequent instillation of eye drops.... Preservative-free eye drops have shown greater effectiveness than preserved drops in decreasing inflammation on the ocular surface and increasing the antioxidant contents in tears of patients with DED."
MIMS: Ophthalmic Preparations, Preservatives and Potential Sensitisers as IngredientsMIMS has listed a number of preservatives commonly found in many eye drop preparations: http://www.mims.co.uk/ophthalmic-preparations-preservatives-potential-sensitisers-ingredients/ophthalmology/article/1100486
How about VISMED® eye drops? Do they contain any preservatives?
The answer is that not only are the single-dose vials (VISMED®, VISMED® GEL) preservative free, but neither do the "Just squeeze" multi-dose bottles (VISMED® MULTI, VISMED® GEL MULTI) contain any preservatives at all. Our multidose bottles (ophthalmic squeeze dispensers) have been specially designed to remain sterile for up to 3 months after first use, whilst being very easy to use and offering a precise and reproducible drop ejection.
These innovative multi-dose bottles have a unique inbuilt system to keep the lubricant free from contaminants. TRB Chemedica was the first company to use the OSD bottles (Ophthalmic Squeeze Dispenser) for VISMED® MULTI. And, in fact, the design of the bottle actually won an award in 2012: