Clinical Studies – Osteoarthritis in Large Joints

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NEW: B Barac, N Damjanov & A Zekovic The new treatment approach in knee osteoarthritis: Efficacy of cellular matrix combination of platelet rich plasma with hyaluronic acid versus two different types of hyaluronic acid (HA)
UPDATE: T Conrozier, et al. EUROVISCO Good Practice Recommendations for a First Viscosupplementation in Patients with Knee Osteoarthritis

M Phillips, et al.

A Systematic Review of Current Clinical Practice Guidelines on Intra-articular Hyaluronic Acid, Corticosteroid, and Platelet-Rich Plasma Injection for Knee Osteoarthritis

T Conrozier, et al.

Viscosupplementation for the treatment of osteoarthritis. The contribution of EUROVISCO group

Z T Lundstrom, T T Sytsma, L S Greenlund

Rethinking Viscosupplementation: Ultrasound- Versus Landmark-Guided Injection for Knee Osteoarthritis

G Gigliucci, et al.

The evidence of surgery delay after viscosupplementation is increasing

L E Miller, M Fredericson, R D Altman

Hyaluronic Acid Injections or Oral Nonsteroidal Anti-inflammatory Drugs for Knee Osteoarthritis - Systematic Review and Meta-analysis of Randomized Trials

L A Wilson, et al.

Increased Use of Intra-Articular Steroid Injection to Treat Osteoarthritis is Associated With Chronic Opioid Dependence After Later Total Knee Arthroplasty But Not Total Hip Arthroplasty

T Conrozier , F Eymard, M Chouk and X Chevalier

Impact of obesity, structural severity and their combination on the efficacy of viscosupplementation in patients with knee osteoarthritis

L C Pereira, et al. 

Gait analysis following single-shot hyaluronic acid supplementation: a pilot randomized double-blinded controlled trial

Dr Robert Hunter, MD 

Evidence supporting the value of high molecular weight hyaluronic acid for the care and treatment for patients with mild to moderate osteoarthritis of the knee

Maheu E, et al. 

Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: Results of an extensive critical literature review. 

Dasa V, Lim S, Heeckt P.

Real-World Evidence for Safety and Effectiveness of Repeated Courses of Hyaluronic Acid Injections on the Time to Knee Replacement Surgery.

D Baron, et al. 

Hyaluronic Acid Single Intra-Articular Injection in Knee Osteoarthritis: A Multicenter Open Prospective Study (ART-ONE 75) with Placebo Post Hoc Comparison

Author links open overlay panel 

Vannabouathong C, et al. 

Nonoperative Treatments for Knee Osteoarthritis: An Evaluation of Treatment Characteristics and the Intra-Articular Placebo Effect: A Systematic Review. 

Salmon JH, et al. 

Cost Effectiveness of Intra-Articular Hyaluronic Acid and Disease-Modifying Drugs in Knee Osteoarthritis. 

D Yalong, et al. 
Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials 
J Bert, et al. 
Viscosupplementation for Osteoarthritis of the Knee: A Key Opinion Leader Panel Discussion 
A Concoff, et al. 
Intra-Articular Hyaluronic Acid Delay to Total Knee Arthroplasty By Number of Injection Courses Received: Analysis of an Administrative Database 
JP Pelletier, et al. 
Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative  
M Bhandari, et al. 
Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective  
A Delbarre, et al. 
Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis – A Cox model analysis 
B Dernek , et al. 
Efficacy of single-dose hyaluronic acid products with two different structures in patients with early-stage knee osteoarthritis 
M Shaikh, V Reddy and D Pyne 
A Comparison of two Hyaluronic Acid Preparations in Patients with Knee Osteoarthritis (Poster) 
B Dernek, et al. 
Therapeutic efficacy of three hyaluronic acid formulations in young and middle-aged patients with early-stage meniscal injuries 
J Posnett, S Dixit, B Oppenheimer, S Kili, N Mehin 
Patient preference and willingness to pay for knee osteoarthritis treatments 
R L Dreiser, et al. 
Efficacy of one intra-articular injection 2% natural sodium hyaluronate is non-inferior to chemically crosslinked Hylan G-F 20 in the treatment of painful tibiofemoral osteoarthritis
A Borras-Verdera, et al. 
Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid and mannitol in knee osteoarthritis over a 6-month period  
K Frobenius 
A new high-dose treatment with intra-articular hyaluronic acid facilitates the management of osteoarthritis 
V Strand, et. al. 
Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta-analysis of randomized, saline-controlled trials 
P Richette, et al. 
Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias  
C A T Davalillo, et al. 
Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone 
L Miller, et al. 
Unraveling the confusion behind hyaluronic acid efficacy in the treatment of symptomatic knee osteoarthritis
A Askari, et al. 
Hyaluronic acid compared with corticosteroid injections for the treatment of osteoarthritis of the knee: a randomized control trial
R Altman, et al. 
Hyaluronic Acid Injections are associated with Delay of Total Knee Replacement Surgery in Patients with Knee Osteoarthritis: Evidence from a large U.S. Health Claims Database 
T H Trojian, et al. 
AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes - Consensus Statement 
K L Ong, et al. 
Hyaluronic Acid Injections in Medicare Knee Osteoarthritis Patients Are Associated With Longer Time to Knee Arthroplasty 
O Bruyère, et al. 
A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis - From evidence-based medicine to the real-life setting 
E Maheu, et al. 
Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys 
R Altman, et al. 
Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery 
RD Altman, et al. 
The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review 
Ted Willis GP 
The increasing demand for knee replacements: a hostage to fortune 
K A Campbell, et al. 
Is Local Viscosupplementation Injection Clinically Superior to other Therapies in the Treatment of Osteoarthritis of the Knee: A Systematic Review of Overlapping Meta-analyses 
L E Miller, J E Block 
An 8-week multimodal treatment program improves symptoms of knee osteoarthritis: a real-world multicenter experience 
F Navarro-Sarabia,  et al. 
A 40-month multicentre, randomised placebocontrolled study to assess the efficacy and carryovereffect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project 
T Willis in PULSE 

Why NICE is wrong on OA: Viscosupplementation, or use of hyaluronan injections, is a very useful, simple  and cost-effective treatment for osteoarthritis of the knee. NICE is wrong to 'not recommend' it. 

Y Henrotin, et al. 

Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters 

Flanagan A 

TRB Chemedica HA Safety Statement June 2012 

Juni P, et al.  

Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial. 

D Uebelhart, et al. 

Safety and efficacy of fermentative hyaluronan in knee osteoarthritis: a retrospective study.

B Mathies, et al. 

Effect of intra-articular sodium hyaluronate (Ostenil®) on improving the quality of life and delaying surgery in patients indicated for total knee replacement. An open, pilot, phase III study 



NEW: G Gigliucci, et al.
The evidence of surgery delay after viscosupplementation is increasing
NEW: P Schiavi, et al.
Efficacy and safety of viscosupplementation with hyaluronic acid for hip osteoarthritis: results from a cross-sectional study with a minimum follow-up of 4 years
L Gorelick, A Rozano-Gorelick, A Saab, E Ram 
Results of Treatment of Greater Trochanteric Pain Syndrome in Diabetic Patients by Single Hyaluronic Acid Injection 
K Frobenius 
A new high-dose treatment with intra-articular hyaluronic acid facilitates the management of osteoarthritis
C Tikiz, et al. 
Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis.
NEW: U Oduoza, M Stoddart, A Majed, D Butt, M Falworth, W Rudge
The Effects of Intra‑Articular Hyaluronate Injections in Young Patients with Glenohumeral Joint Osteoarthritis
NEW: J. Mehl, A. B. Imhoff, K. Beitzel 
Osteoarthritis of the shoulder: pathogenesis, diagnostics and conservative treatment options 
L Osti, et al. 
Clinical evidence in the treatment of rotator cuff tears with hyaluronic acid - Review Article 
Saito S, et al. 
Therapeutic effects of hyaluronate injections in patients with chronic painful shoulder: A meta-analysis of randomized controlled trials. 
Lennard Funk
Hyaluronan vs Steroid Injection for Subacromial Impingement of the Shoulder 
Lennard Funk 
Ostenil Hyaluronan for Inoperable Arthritis of the Shoulder 
NEW: S Taylor, et al.
A single centre, open label, pilot study evaluating the effect of intra-articular hyaluronic acid injection on pain and functionality when injected into the ankle (tibio-talar and sub-talar) joint in patients with haemophilic arthropathy
E P Murphy, et al. 
Prospective Evaluation of Intra-Articular Sodium Hyaluronate Injection in the Ankle 
T B Faleiro, et al. 
Viscosupplementation in Ankle Osteoarthritis: A Systematic Review 
R Petrella, et al. 
Long-Term Efficacy and Safety of Periarticular Hyaluronic Acid in Acute Ankle Sprain
NEW: T Conrozier, et al.
EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis 
Yves Henrotin, et al. 
Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis