Extending the Reach of Non-Surgical Knee OA Management with Ostenil Plus

Knee osteoarthritis (OA) is a prevalent degenerative joint condition leading to significant mobility impairment and diminished quality of life. Among the spectrum of therapeutic strategies for knee OA management, intra-articular injections have carved a niche. One notable contender in this domain is Ostenil Plus, a formulation by TRB Chemedica. This piece explores the merits of Ostenil Plus, enriched with insights from ACTIVATE Musculoskeletal Clinic in Kent and a compilation of relevant research data.

Understanding the Mechanism of Ostenil Plus

Ostenil Plus is a distinctive formulation of hyaluronic acid (HA), tailored to mitigate the symptoms of osteoarthritis. When injected into the synovial space of the affected joint, it serves to restore the equilibrium between the degradation and replenishment of hyaluronic acid, thereby alleviating pain and stiffness, and enhancing joint functionality. The formulation is further optimized with the inclusion of Mannitol, a sugar derivative that stabilizes the hyaluronic acid chains, thus augmenting the efficiency and longevity of symptom relief with a singular injection.

Ostenil Plus Versus Steroid Injections: A Comparative Lens

Corticosteroid injections, known for their rapid anti-inflammatory action, provide temporary relief typically lasting 4 to 8 weeks. In contrast, Ostenil Plus mediates the symptoms of OA in a more physiologic manner, with no adverse potential to joint architecture, often rendering a prolonged benefit. This distinction underscores the appeal of Ostenil Plus for patients desiring sustained relief, especially in knee OA scenarios where inflammation is not markedly present.

Ostenil Plus Knee Injection

Empirical Evidence: The Efficacy of Ostenil Plus

The effectiveness of hyaluronic acid products like Ostenil Plus is supported by numerous empirical research papers from reputable sources. The Cochrane Review, an esteemed entity in evidence-based healthcare, advocates the use of HA products for managing mild to moderate knee osteoarthritis. Additionally, a systematic review of Clinical Practice Guidelines globally echoed a favourable disposition towards intra-articular hyaluronic acid (IA-HA) injections for symptomatic relief in knee OA when other non-surgical avenues fall short.

Reflections from the Field: ACTIVATE Musculoskeletal Clinic

Dr. Mustafa Alnaib at ACTIVATE Musculoskeletal Clinic in Kent affirms the efficacy of Ostenil Plus, recounting over two years of successful administration to knee OA patients. The patients' feedback has been overwhelmingly positive, highlighting substantial pain alleviation for 6 to 12 months post-injection. This real-world testimony accentuates the potential of Ostenil Plus as a formidable contender in non-surgical knee OA management.

A Look at Pricing and Accessibility

Relative affordability is one of the hallmarks of Ostenil Plus, especially when compared with the financial burden of surgical interventions or recurrent corticosteroid injections over time.

Concluding Thoughts

The journey towards non-surgical management of knee OA is being propelled forward by innovations like Ostenil Plus. The confluence of clinical evidence, real-world affirmations, and a high safety profile renders Ostenil Plus a commendable choice in the knee OA management continuum. The experiences echoed by ACTIVATE Musculoskeletal Clinic further fortify the stance for considering Ostenil Plus in routine knee OA therapeutic regimens.


This blog aims to engender an informed discussion on knee OA management alternatives and is not to be construed as medical advice. It's imperative to consult with healthcare professionals for personalized medical guidance.


Dr Mustafa Alnaib MBChB MRCS MSc FEBOT

Clinic Director | ACTIVATE Musculoskeletal Clinic


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